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School of Engineering

People Steven Little

Assistant Professor and Bicentennial Alumni Faculty Fellow

Departments of Chemical Engineering, Bioengineering, Immunology and the McGowan Institute for Regenerative Medicine

srlittle@pitt.edu

Phone: 412-624-9614

Fax: 412-624-9639

Office: 1237 Benedum Hall / 5057 BST3

Education

PhD Chemical Engineering, Massachusetts Institute of Technology, 2005

BE Chemical Engineering, Youngstown State University, 2000

Professional Interests

Researchers in our labs focus upon therapies that are biomimetic in that they replicate the biological function and interactions of living entities using synthetic systems. To find out more about biomimetic systems and strategies, and to listen to our researchers talk about their projects, visit:

http://www.littlelab.pitt.edu

We collaborate heavily with faculty from The McGowan Institute for Regenerative Medicine, the Starzl Institute of Transplantation, and The Center for Craniofacial Regeneration.

FUNDING SOURCES

National Institutes of Health, Department of Defense, ?Arnold and Mabel Beckman Foundation, American Heart Association

Selected Publications

Rothstein, S.N., Federspiel W. J., Little, S.R. (2009), A Unified Mathematical Model for the Prediction of Controlled Release from Surface and Bulk Eroding Polymer Matrices (Biomaterials 30(8): 1657-64)

van Vlerken, L.E., Duan, Z, Little, S.R., Seiden, M.V., Amiji, M, (2008) Biodistribution and Pharmacokinetic Analysis of Paclitaxel and Ceramide Administered in Multifuncitonal polymer-Blend nanoparticles in Drug Resistant Breast Cancer Model. (Mol Pharmaceutics, 5(4) 516-26)  

     

Jhunjhunwala, S, Raimondi, G., Thomson, A., Little, S.R., (2009) Delivery Of Rapamycin To Dendritic Cells Using Degradable Microparticles  (Journal of Controlled Release, 133: 191-97)

Brito, L., Little, S.R., Langer, R, Amiji, M., Poly (β-amino ester) and Cationic Phospholipid-Based Lipopolyplexes for Gene Delivery and Transfection in Human Aortic endothelial and Smooth Muscle Cells. (Biomacromolecules, E-pub ahead of print 2/29/08)

 

Rothstein, S.N., Federspiel W. J., Little, S.R., (2008)  A Simple Model Framework for the Prediction of Controlled Release from Hydrated Biodegradable Polymer Matrices. (Journal of Materials Chemistry, 18, 1873-80)

Little, S.R., Kohane, D.S. (2008) Polymers for Intracellular Delivery of Nucleic Acids (Journal of Materials Chemistry 18, 832 - 41)

Choleris, E., Little, S.R., Mong, J.A., Puram, S.V., Langer, R., Pfaff, D.W. (2007) Functional mRNA  for oxytocin receptor required in the amygdala to support social recognition (Proceedings of the National Academy of Sciences, 104(11): 4670-75)

Zugates, G. T., Anderson, D. G., Little, S.R., Lawhorn, E.B., Langer, R., (2006) Synthesis of Poly(beta-amino ester)s with Thiol-Reactive Side Chains for DNA Delivery (Journal of the American Chemical Society, 128(39):12726-34)

Devalapally, H.,  Shenoy, D., Little, S.R., Langer, R., Amiji, M. (2006) Poly(Ethylene Oxide)- Modified Poly(Beta-Amino Ester) Nanoparticles as a pH-Sensitive System for Tumor-Targeted Delivery of Hydrophobic Drugs: Part 3. Therapeutic Efficacy and Toxicity Studies in Ovarian Cancer Xenograft Model (Cancer Chemotherapy and Pharmacology, 59(4): 477-84)

Little, S.R., Langer, R., (2005) Advancements in non-viral delivery of cancer genetic vaccines. (Advances in Biochemical Engineering/Biotechnology, 99: 93-118)

Pfeifer, B.A., Burdick, J.A., Little, S.R., Langer, R., (2005) Poly(ester-anhydride):poly(β-amino ester)Micro- and Nanospheres: DNA Encapsulation and Cellular Transfection. (International Journal of Pharmaceutics, 304(1-2): 210-9)

Wood, K.C., Little, S.R., Langer, R., Hammond, P.T. (2005) A New Family of Hierarchically Self-Assembling Linear-Dendritic Hybrid Polymers for Highly Efficient, Targeted Gene Delivery (Angewandte Chemie, 44(41): 6704-8)  Highlighted in: A Synthetic Solution to Gene Delivery. (2005) Nature Methods 2(11): 808

Zugates, G.T., Little, S.R., Anderson, D.G., Langer, R., (2005) Poly(β-amino ester)s for DNA Delivery. (Israel Journal of Chemistry, 45: 477-85)

Shenoy, D., Little, S.R., Langer, R., Amiji, M. (2005) Poly(Ethylene Oxide)-Modified Poly(β-Amino Ester) Nanoparticles as a pH-Sensitive System for Tumor-Targeted Delivery of Hydrophobic Drugs: Part II. In Vivo Distribution and Tumor Localization Studies. (Pharmaceutical Research, 22(12): 2107-14)

Shenoy, D., Little, S.R., Langer, R., Amiji, M. (2005) Poly(Ethylene Oxide)-Modified Poly(β-Amino Ester) Nanoparticles as a pH-Sensitive System for Tumor-Targeted Delivery of Hydrophobic Drugs: Part I. In Vitro Evaluations. (Molecular Pharmaceutics, 2(5): 357-66)

Little, S.R., Lynn, D.M., Puram, S.V., Langer, R.S., (2005) Formulation and Characterization of Poly(β-amino ester) microparticles for genetic vaccine delivery. (Journal of Controlled Release, 107(3): 449-62)

Haining, N.W., Anderson, D.G., Little, S.R., Bergwelt, M., Cardoso, A.A., Alves, P., Kosmatopoulos, K., Nadler, L.M., and Langer, R., Kohane, D.S. (2004) pH-triggered microparticles for vaccination. (Journal of Immunology, 15;173(4): 2578-85)  Highlighted in: Timing is Everything. (2004) Nature Methods 1(1)), 9

Little, S.R., Lynn, D.M., Ge, Q., Anderson D.G.,  Puram S.V., Chen J., Eisen H.N., Langer R.. (2004) Novel microparticles enhance the potency of non-viral genetic vaccines (Proceedings of the National Academy of Sciences, 101(26): 9534-39)

 

Benedum Hall

Dedicated in 1971, Benedum Hall is home to exploration and discovery.

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