People William Federspiel
W.K. Whiteford Professor Departments of Chemical Engineering, EducationPhD (Chemical Engineering), University of Rochester, 1983 Professional InterestsDr. William J. Federspiel joined the faculty of the University of Pittsburgh in 1995 as an Associate Professor. He received his PhD in Chemical Engineering from the University of Rochester in 1984 and has held academic positions in biomedical engineering at Johns Hopkins University and Boston University. His past industrial experience includes being a Principal Staff Scientist at ABIOMED Inc., a Boston based artificial heart company, and a Research Scientist at the Biomechanics Institute in Boston, a nonprofit bioengineering think-tank. In addition to his current academic position, Dr. Federspiel is a Founder of Alung Technologies, a Pittsburgh based medical start-up company, for which he currently serves as Chief Scientific Officer. Currently, Dr. Federspiel is William Kepler Whiteford Professor of Chemical Engineering, Surgery and Bioengineering. His research interests span from basic studies on respiratory and cardiovascular fluid mechanics and mass transport to translational studies on the design and development of novel biotransport, pulmonary and cardiovascular medical devices and technologies, including respiratory assist devices or artificial lungs, blood purification devices, and drug delivery devices (see publications). He directs research in the Medical Devices Laboratory: Biotransport, Pulmonary and Cardiovascular, a core laboratory of the McGowan Institute for Regenerative Medicine. The major research theme of the laboratory is the development of medical devices whose therapeutic function stems from biotransport and bioseparation processes and which can be translated for near-term clinical use in critical care medicine. Dr. Federspiel's current research projects include development work on the following devices and technologies:
Selected PublicationsFederspiel WJ. Basic transport phenomena in biomedical engineering: a review. ASAIO J. In press. Eash HJ, Mihelc KM, Frankowski BJ, Hattler BG, Federspiel WJ. Evaluation of fiber bundle rotation for enhancing gas exchange in a respiratory assist catheter. ASAIO J. In press. Engelmayr GC, Soletti L, Vigmostad SC, Budilarto SG, Federspiel WJ, Chandran KB, Vorp DA, Sacks MS. A novel flex-stretch-flow bioreactor for the study of heart valve tissue mechanobiology. Annals of Biomedical Engineering. In press. Solovan JC, Oh HI, Alikhani A, Gautam S, Vlasova K, Korchagina EY, Bovin NV, Federspiel WJ. Synthetic blood groups antigens for anti-A removal device and their interaction with monoclonal anti-A IgM. Transplantation Immunology 16: 245-249, 2006. Eash HJ, Budilarto SG, Hattler BG, Federspiel WJ. Investigating the effects of random balloon pulsation on gas exchange in a respiratory assist catheter. ASAIO J. 52: 192-195, 2006. Snyder TA, Eash HJ, Litwak KN, Frankowski BJ, Hattler BG, Federspiel WJ, Wagner WR. Blood biocompatibility assessment of an intravenous gas exchange device. Artif Organs. 30(9): 657-664, 2006. Svitek RG, Frankowski BJ, Federspiel WJ: Evaluation of a pumping assist lung that uses a rotating fiber bundle. ASAIO J. 51: 773-780, 2005. Budilarto SG, Eash HJ, Frankowski BJ, Hattler BG, Federspiel WJ. Flow visualization study of a pulsating respiratory assist catheter. ASAIO J. 51: 673-680, 2005. Kanick SC, Doyle WJ, Ghadiali SN, Federspiel WJ. Differences between two methods of measuring diffusions length in the predicted oxygen diffusing capacity of the middle ear mucosa. J. Appl. Physiol. 98: 114- 119, 2005. Eash HJ, Frankowski BJ, Hattler BG, Federspiel WJ. Evaluation of local gas exchange in a pulsating respiratory support catheter. ASAIO J. 51:152-157, 2005. Eash HJ, Jones HM, Hattler BG, Federspiel WJ. Evaluation of plasma resistant hollow fiber membranes for artificial lungs. ASAIO J. 50:491- 497. 2004. Nolan TDC, Hattler BG, Federspiel WJ. Development of a balloon volume sensor for pulsating balloon catheters. ASAIO J.50:225-233. 2004. Eash HJ, Frankowski BJ, Litwak K, Wagner WR, Hattler BG, Federspiel WJ. Acute in-vivo testing of a respiratory support catheter: Implants in calves versus sheep. ASAIO J. 49: 370-377, 2003. Hout MS, Federspiel WJ. Mathematical and experimental analyses of antibody transport in hollow fiber-based specific antibody filters. Biotech. Prog. 19: 1553-1561, 2003. Garcia MY, Hattler BG, Federspiel WJ. Effect of vessel compliance on the in-vitro performance of a pulsating respiratory support catheter. J. Biomech. Eng.: 124(2): 56-62, 2002. Lai J, Gouldstone A, Butler JP, Federspiel WJ, Loring SH. Relative motion of lung and chest wall promotes uniform pleural space thickness. Resp. Physiol & Neurobiology 131: 233-243, 2002. Hattler BG, Lund LW, Golob J, Russian H, Lann MF, Merrill TL, Frankowski B, Federspiel WJ. A respiratory gas exchange catheter: in vitro and in vivo tests in large animals. J. of Thorac. Cardiovasc. Surg.: 124(3): 520-30, 2002. Ghadiali SN, Swarts JD, Federspiel WJ. Model-based evaluation of Eustachian tube mechanical properties using continuous presssure-flow rate data. Ann. Biomed. Eng. 30: 1064-1067, 2002. Drevon GF, Danielmeier K, Federspiel W, Stolz DB, Wicks DA, Yu PC, Russell AJ. High activity enzyme-polyurethane coatings. Biotech. Bioeng. 79 (7): 785-794 2002. Lund LW, Hattler BG, Federspiel WJ. A comparative in vitro hemolysis study of a pulsating intravenous artificial lung. ASAIO J. 48 (6): 631-635, 2002. |
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