People Faculty

Sanjeev G. Shroff, Ph.D.

Associate Chair, Department of Bioengineering
Professor and Gerald McGinnis Chair in Bioengineering
Professor of Medicine
Senior Investigator, Magee-Womens Research Institute
Core Faculty, McGowan Institute for Regenerative Medicine

Email:
Phone:	(412) 624-2095
Fax:	(412) 383-8788
Office:	CNBIO 308

Education

Ph.D. Bioengineering University of Pennsylvania, Philadelphia, PA
M.Eng. Electrical Engineering McMaster University, Ontario, Canada
B.Tech. Electrical Engineering Indian Institute of Technology, Kanpur, India

Professional Interests

Dr. Shroff's research interests include three main areas: (1) Contractile and regulatory proteins and whole heart function, (2) Vascular stiffness and cardiovascular function, and (3) Large-scale mathematical simulations of biological systems for research, education, and engineering design.

An evaluation of the relationships between left ventricular mechano-energetic function and underlying cellular processes, with a special emphasis on contractile and regulatory proteins, is the focus of the first research area. Whole heart, isolated muscle, and single cell experiments are performed using various animal models, including transgenic mice.

The second research area focuses on the role of pulsatile arterial load (vascular stiffness in particular) in cardiovascular function. One of the hypotheses being investigated is that aberrant vascular stiffness changes are involved in the genesis of certain cardiovascular pathologies (e.g., preeclampsia, isolated systolic hypertension in elderly). Novel noninvasive measurement techniques are used to conduct longitudinal human studies, which are complimented by in-vivo and in-vitro vascular and cardiac studies with animal models.

Regarding the third focus area, Dr. Shroff and colleagues have developed and continue to develop novel, simulation-based material (i.e., mathematical models of biological systems and associated "virtual experiments") for education and engineering design.

Dr. Shroff's collaborators include basic and clinical scientists at Pittsburgh, PA (Magee-Womens Research Institute, Cardiovascular Institute, McGowan Institute for Regenerative Medicine, Allegheny General Hospital), Chicago, IL (University of Chicago Medical Center, Illinois Institute of Technology), and Pullman, WA (Washington State University).

Dr. Shroff's professional affiliations include:

Fellow, Cardiovascular Section, American Physiological Society
Fellow, American Institute for Medical and Biological Engineering
American Heart Association, Council on Basic Research and Circulation Council
Biomedical Engineering Society
Biophysical Society
American Society for Engineering Education

Selected Publications

Berger DS, Robinson KA, Shroff SG. Wave propagation in coupled left ventricle–arterial system: Implications for aortic pressure. Hypertension 27:1079–1089, 1996.
Poppas A, Shroff SG, Korcarz CE, Hibberd JU, Berger DS, Lindheimer MD, Lang RM. Serial assessment of cardiovascular system in normal pregnancy: role of arterial compliance and pulsatile arterial load. Circulation 95:2407–2415, 1997.
Seow C, Shroff SG, Ford L. Detachment of low–force bridges contributes to the rapid tension transients of skinned rabbit skeletal muscle fibres. J. Physiol. (London) 501:149–164, 1997.
Fentzke RC, Korcarz CE, Shroff SG, Lin H, Sandelski J, Leiden JM, Lang RM. Evaluation of ventricular and arterial hemodynamics in anesthetized, closed–chest mice. J. Am. Soc. Echocardiogr. 10:915–925, 1997.
Berger DS, Vlasica K, Quick CM, Robinson, KA, Shroff SG. Ejection has both positive and negative effects on left ventricular isovolumic relaxation. Am. J. Physiol. 273 (Heart Circ. Physiol. 42):H2696–H2707, 1997.
Berger DS, Fellner SK, Robinson, KA, Vlasica K, Godoy IE, Shroff SG. Disparate effects of three types of extracellular acidosis on left ventricular function. Am. J. Physiol. 276 (Heart Circ. Physiol. 45):H582–H594, 1999.
Cholley BP, Lang RM, Korcarz C, Shroff SG. Smooth muscle relaxation and local hydraulic impedance properties of the aorta. J. Appl. Physiol. 90:2427–2438, 2001.
Collins KA, Korcarz CE, Shroff SG, Bednarz JE, Fentzke RC, Lin H, Leiden JM, Lang RM. Accuracy of echocardiographic estimates of left ventricular mass in mice. Am. J. Physiol. Heart Circ. Physiol. 280:H1954–H1962, 2001.
Fentzke RC, Korcarz CE, Shroff SG, Lin H, Leiden JM, Lang RM. The left ventricular stress-velocity relationship in transgenic mice expressing a dominant negative CREB trasgene in the heart. J. Am. Soc. Echocardiogr. 14:209–218, 2001.
MacGowan, G.A., & Shroff, S.G. (2003). The myofilament force-calcium relationship and left ventricular function. Recent Research Development Physiol., 1, 873-889.
Wu, H-C., Chen, J. S-Y., Shroff, S.G., & Carroll, J.D. (2003). Stress analysis using anatomically realistic coronary tree and plaque subject to cardiac cyclic flexion. Med. Phys., 30(11), 2927-2936.
Conrad, K.P., Debrah, D.O., Novak, J., Danielson, L.A., & Shroff, S.G. (2004). Relaxin modifies systemic arterial resistance and compliance in conscious, nonpregnant rats. Endocrinology, 145, 3289-3296.
Hibbard, J.U., Shroff, S.G., & Lang, R.M. (2004). Cardiovascular changes in preeclampsia. Semin. Nephrol., 24, 580-587.
MacGowan, G., Evans, C., Hu, T.C-C., Debrah, D.O., Mullet, S., Chen, H-H., McTiernan, C.F., Stewart, A.F.R., Koretsky, A.P., & Shroff, S.G. (2004). Troponin I protein kinase C phosphorylation sites and ventricular function. Cardiovascular Research, 63, 245-255.
Campbell, K.B., Wu, Y., Simpson, A.M., Kirkpatrick, R.D., Shroff, S.G., Granzier, H.L., and Slinker, B.K. (2005). Dynamic myocardial contractile parameters from left ventricular pressure/volume measurements. Am. J. Physiol. Heart Circ. Physiol., 289, H114-H130.
Debrah, D.O., Conrad, K.P., Danielson, L.A., and Shroff, S.G. (2005). Effects of relaxin on systemic arterial hemodynamics and mechanical properties in conscious rats: Sex dependency and dose response. J. Appl. Physiol., 1041, 155-162.
Debrah, D.O., Conrad, K.P., Jeyebalan, A., Danielson, L.A., and Shroff, S.G. (2005). Relaxin increases cardiac output and reduces systemic arterial load in hypertensive rats. Hypertension, 46, 745-750.
Debrah, D.O., Conrad, K.P., Novak, J., Danielson, L.A., and Shroff, S.G. (2005). Recombinant human relaxin (rhRLX) modifies systemic arterial properties in conscious rats irrespective of gender, but in a biphasic fashion. Ann. N. Y. Acad. Sci, 98, 1013-1020.
Hibbard, J.U., Korcarz, C.E., Giradet-Nendaz, G., Lindheimer, M.D., Lang, R.M., and Shroff, S.G. (2005). The arterial system in pre-eclampsia and chronic hypertension with superimposed pre-eclampsia. British J. Obstet. Gynecol,. 112, 1-7.
MacGowan, G.A., Rager, J., Shroff, S.G., and Mathier, M.A. (2005). In-vivo ?-adrenergic responses and troponin I phosphorylation: Anesthesia interactions. J. Appl. Physio., 98, 1163-1170.