|
Steven Little, Ph.D.
Assistant Professor, Chemical Engineering, Bioengineering, Immunology, and The McGowan Institute for Regenerative Medicine.
Education
Ph.D., Massachusetts Institute of Technology
Research
My laboratory is focused on biomaterial design and synthetic drug delivery systems. The focus of my research lies in 2 areas: 1) immunoprophylactic and immunotherapeutic formulations which exploit molecular understanding of immune cell interactions. 2) regenerative medicine strategies that use materials to manipulate cell function through surface interactions and controlled release. We work heavily with systems which are biomimetic in that they replicate biological function and interactions using completely synthetic materials. We collaborate heavily with faculty from The McGowan Institute for Regenerative Medicine, the Starzl Institute of Transplantation, and The School of Dental Medicine.
Funding Sources
National Institutes of Health
American Heart Association
Selected Publications
- Little, S.R., Lynn, D.M., Ge, Q., Anderson D.G., Puram S.V., Chen J., Eisen H.N., Langer R.. (2004) Poly(ß-amino ester) microparticles enhance the potency of non-viral genetic vaccines (Proceedings of the National Academy of Sciences, 101(26): 9534-9539).
- Haining, N.W., Anderson, D.G., Little, S.R., Bergwelt, M., Cardoso, A.A., Alves, P., Kosmatopoulos, K., Nadler, L.M., and Langer, R., Kohane, D.S. (2004) pH-triggered microparticles for vaccination. (Journal of Immunology, 15;173(4): 2578-2585).
- Little, S.R., Lynn, D.M., Puram, S.V., Langer, R.S., (2005) Formulation and Characterization of Poly(ß-amino ester) microparticles for genetic vaccine delivery. (Journal of Controlled Release, 107(3): 449-62).
- Shenoy, D., Little, S.R., Langer, R., Amiji, M. (2005)
Poly(Ethylene Oxide)-Modified Poly(ß-Amino Ester) Nanoparticles as a pH-Sensitive
System for Tumor-Targeted Delivery of Hydrophobic Drugs: Part I. In Vitro Evaluations.
(Molecular Pharmaceutics, 2(5): 357-66).
- Shenoy, D., Little, S.R., Langer, R., Amiji, M. (2005)
Poly(Ethylene Oxide)-Modified Poly(ß-Amino Ester) Nanoparticles as a pH-Sensitive
System for Tumor-Targeted Delivery of Hydrophobic Drugs: Part II. In Vivo Distribution
and Tumor Localization Studies. (Pharmaceutical Research, 22(12): 2107-14).
- Wood, K.C., Little, S.R., Langer, R., Hammond, P.T. (2005)
A New Family of Hierarchically Self-Assembling Linear-
Dendritic Hybrid Polymers for Highly Efficient, Targeted
Gene Delivery (Angewandte Chemie, 44(41): 6704-8).
- Little, S.R., Langer, R., (2005) Advancements in non-viral delivery of cancer genetic vaccines. (Advances in Biochemical Engineering/Biotechnology, 99: 93-118).
- Devalapally, H., Shenoy, D., Little, S.R., Langer, R., Amiji,
M. (2006) Poly(Ethylene Oxide)-Modified Poly(Beta-
Amino Ester) Nanoparticles as a pH-Sensitive System for
Tumor-Targeted Delivery of Hydrophobic Drugs: Part 3.
Therapeutic Efficacy and Toxicity Studies in Ovarian Cancer
Xenograft Model (Cancer Chemotherapy and Pharmacology,
59(4): 477-84).
- Zugates, G. T., Anderson, D. G., Little, S.R., Lawhorn, E.B.,
Langer, R., (2006) Synthesis of Poly(b-amino ester)s with
Thiol-Reactive Side Chains for DNA Delivery (Journal of the
American Chemical Society, 128(39):12726-34).
- Choleris, E., Little, S.R., Mong, J.A., Puram, S.V., Langer, R.,
Pfaff, D.W. (2007) Functional mRNA for oxytocin receptor
required in the amygdala to support social recognition
(Proceedings of the National Academy of Sciences, 104(11):
4670-4675).
|
