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Andrzej M. Janczewski, M.D., Ph.D.
Research Assistant Professor, Department of Bioengineering
| Email: |
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| Phone: |
(412) 624-6497 |
| Fax: |
(412) 383-8788 |
| Office: |
737 Benedum Hall |
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Education
M.D. Warsaw Medical School, Warsaw, Poland
Ph.D. (Cardiac physiology) Department of Clinical Physiology, National
Center of Postgraduate Medical Education, Warsaw, Poland
Professional Interests
Excitation-contraction coupling and regulation of cardiac contractility
at the molecular, cellular, tissue, and organ level in the normal
and failing heart.
The current projects are carried out in genetically engineered
(a) experimental models of heart failure, (b) tissues, and (c) cells.
The employed experimental techniques include:
- Measurements of membrane current and voltage using whole-cell
patch-clamp
- Microfluorometry using Ca2+-sensitive fluorescent probes
- Measurements of myocyte and sarcomere shortening dynamics in
isolated cells
- Measurements of contractile force in intact or chemically "skinned"
isolated cardiac preparations and isolated hearts
Selected Publications
- Tobita K, Liu LJ, Janczewski AM, Tinney JP, Nonemaker JM, Augustine S, Stolz DB, Shroff SG, Keller BB. Engineered early embryonic cardiac tissue (EEECT) retains proliferative and contractile properties of developing embryonic myocardium. American Journal of Physiology 2006 (In Press/ available online)
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Saba S*, Janczewski AM*, Baker LC, Shusterman V, Gursoy EC, Salama G, McTiernan CF, London B. Atrial contractile dysfunction, fibrosis, and arrhythmias in a mouse model of cardiomyopathy secondary to cardiac-specific overexpression of TNF-?. American Journal of Physiology 289: H1456-H1467, 2005. (*Equal contributors)
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Janczewski, A.M., Zahid, M., Lemster, B.H., Frye, C., Higuchi, Y., Kranias, E., Feldman, A.M., & McTiernan, C.F. (2004). Phospholamban gene ablation improves calcium transients but not cardiac function in a transgenic heart failure model. Cardiovascular Research, 62, 468-480.
- Andrzej M. Janczewski, Toshiaki Kadokami, Bonnie H. Lemster,
Carol S. Frye, Charles F. McTiernan, and Arthur M. Feldman. Morphological
and functional changes in cardiac myocytes isolated from mice
overexpressing TNF-alpha. American Journal of Physiology 284:
H960-H969 (2003)
- Andrzej M. Janczewski, Harold A. Spurgeon, and Edward G. Lakatta.
Action potential prolongation in cardiac myocytes of old rats
is an adaptation to sustain youthful intracellular Ca2+ regulation.
Journal of Molecular and Cellular Cardiology 34: 641-648 (2002)
- Andrzej M. Janczewski, Edward G. Lakatta, and Michael D. Stern.
Voltage independent changes in L-type Ca2+ current uncoupled from
SR Ca2+ release in cardiac myocytes. American Journal of Physiology
279: H960-H969 (2000)
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