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Graduate Courses BIOE 2220

BIOE 2220 - Cardiovascular Biomaterials & Tissue Engineering

Instructor: Wagner

Credits: 3

Term:

Description: This course is designed to acquaint students with a more advanced understanding of cardiovascular biomaterials and biocompatibility while also presenting current issues and theories in cardiovascular tissue engineering.

Prerequisites: BIOE 2810 or equivalent

Required Texts: Recommended: Biomaterials Science, (eds.)Ratner, Hoffman, Schoen and Lemons, Academic Press (1996).

Course Objectives: At the conclusion of this course students should:

  1. know the basic biological processes that occur during blood contact with artificial surfaces,
  2. be able to critically read and review the literature in the field of cardiovascular biomaterials and tissue engineering,
  3. have the necessary skills to anticipate biocompatibility issues relevant to a variety of cardiovascular devices that the student may encounter in future endeavors,
  4. have an understanding of current approaches directed toward the engineering of cell-based replacements for cardiovascular tissue,
  5. have developed their abilities to digest, organize, and effectively present technical material to a group of their peers.

Topics Covered: Approach: The course will alternate meetings between lecture and discussion. An overview lecture on a particular topic will be given at one meeting and at the next meeting the class will discuss research articles students have selected for the previous meeting’s topic. For discussion days, please bring in a copy of your articles for everyone in class (and the instructor). It is recommended that students make a "note" sheet for the papers they have read, but this does not have to be turned in.

  1. Protein Adsorption
  2. Coagulation
  3. Platelets
  4. Cell Adhesion/Integrins
  5. Endothelial Cells
  6. Matrices for Tissue Engineering
  7. Smart Biomaterials
  8. Tissue Engineered Heart Valves
  9. Tissue Engineered Blood Vessels
  10. Infection in Cardiovascular Devices

Syllabus: Microsoft Word Format

Class/Laboratory Schedule: Tu, Th 2:30-3:45

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