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School of Engineering

Graduate NIH Training in Biotechnology

Trainees

Andrew Kim

Project Description

Protein aggregation is the chief mode of product degradation in the bioprocessing of therapeutic drugs and can lead to reduced bioactivity and altered immunogenicity. The weak protein interactions that lead to aggregation are quantified by the osmotic second virial coefficient (B22) which can be measured by using a novel technique, self-interaction chromatography (SIC). We plan to use SIC, in conjunction with site-directed mutagenesis and modeling, to develop a rational high-throughput screening method for formulations that minimize protein aggregation. To enable parallel experimentation, we will design and fabricate a miniaturized SIC device.

Courses

Foundations Course (2005)

Molecular Biophysics I

Molecular Biophysics II

Scientific Ethics

Placed out of Fundamentals of Biochem E

Physical Biochemistry

Advanced Thermodynamics

Advanced Fluid Mechanics

Publications

None

Presentations

Chemical Engineering Graduate Student Association Symposium 2006 - Carnegie Mellon University - Poster presentation

Seminars

CMU Chemical Engineering, CMU Biomedical Engineering

 

Advisor

Todd Przybycien
Head of Biomedical Engineering and Professor of Chemical Engineering and Biomedical Engineering

Carnegie Mellon University

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